The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences. Presently there are 23 research groups with a total of about 350 employees and guest researchers. In addition to a highly interactive and international scientific environment, excellent research facilities are available for imaging and functional genomics. Moreover, several model organisms are present, including C. elegans, zebrafish and rodents. The institute is situated at the Utrecht Science Park. The Hubrecht Institute is affiliated with the University Medical Center Utrecht and has close connections with Utrecht University, e.g. in the graduate school Cancer, Stem cells & Developmental biology.

The groups of Dr. Francesca Mattiroli and Dr. Puck Knipscheer currently have a vacancy for a


to work on Protein expression and purification

  • Full time (38 hours/week)
  • Starting date: as soon as possible
  • Location: Utrecht Science Park, De Uithof

Description of the project

We are looking for a (senior) technician to perform protein expression and purification procedures at the Hubrecht Institute. The main task will be to express recombinant proteins in bacteria, insect cells and mammalian cells, followed by purification using automated chromatography procedures (FPLC). The successful candidate will work within the laboratories of Dr. Mattiroli and Dr. Knipscheer, with access to biochemistry expertise and state-of-the-art equipment. The tasks will also include the design and optimization of purification strategies, and collaboration with additional groups within the Institute on various projects. The experiments need to be well documented and clearly communicated.


The candidate should have a bachelor or master degree in biology, biomedical sciences or biochemistry (HBO or University level). A strong affinity (preferably hands-on experience) with cell culture, recombinant protein expression and protein purification is a requirement. Since the position involves working on various projects simultaneously, a skill in working systematically is needed. An enthusiastic and independent work attitude are recommended and good communication skills are a prerequisite.


Initially one year with a potential extension.


According to “CAO-Nederlandse Universiteiten” (CAO-NU), depending on experience scale 7 excluding 8% holiday allowance and an 8.3% year-end bonus. We offer an extensive package of fringe benefits.


For additional information please contact Dr. F. Mattiroli,, Dr. P. Knipscheer or visit the website


Please send your application before November 1st, 2020 including curriculum vitae and contact details of three potential references  to, stating vacancy HUBR-2020-15 in the subject line.

Any acquisition further to this advertisement will not be appreciated.

Key words: Vacancy, Laboratory Research, Analist, Technician, Biology, Biomedical sciences, Biochemistry, Biochemie, Laboratoriumonderzoek, Laboratoriumtechniek, HLO, HBO, Master, WO, Utrecht.